SafeStitch LLC was originally founded by Charles J. Filipi M.D. and Jeffrey G. Spragens, along with Creighton University, in 2005, to develop a prototype for a minimally invasive obesity procedure.

In the summer of 2006, Phillip Frost M.D., Founder, CEO and Chairman of IVAX Corporation and Jane Hsiao Ph.D., Vice-Chairman of IVAX Corporation, became partners in SafeStitch LLC and expanded SafeStitch’s mission to become a comprehensive medical device company to develop numerous devices in the areas of Bariatric Surgery, Reflux Interventions, Barrett’s Esophagus, Hernia Repair, NOTES (NO SCAR) Surgery and more.

In September 2007, SafeStitch LLC completed a share exchange with Cellular Technical Services Company, a publicly-traded company, which has since been renamed SafeStitch Medical Inc.